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Future trials should prioritize sufficient duration ( 1218 months), include high-risk subgroups (e.g., older adults, frail individuals, patients with rapid or marked weight loss, or chronic comorbidities such as chronic kidney disease), and integrate nutritional and resistance training interventions

Branded medications such as Wegovy, Zepbound, and Foundayo have undergone rigorous FDA review, providing consistent dosing and safety data from extensive clinical trials

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Network Geometry Figure 3 depicts the geometry of the treatment network for percentage body weight change

Semaglutide is not recommended for those with a history of thyroid cancer, type-1 diabetes, history or pancreatitis, people who are pregnant, or if on other blood sugar lowering medications

Cardiovascular death was reduced by 22% (HR 0.78) and all-cause mortality by 15% (HR 0.85)