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If you are curious about how semaglutide compares to other compounds sometimes discussed in similar regulatory contexts, the breakdown of semaglutide vs tirzepatide is worth reading

Xie Y, Bowe B, Xian H, Loux T, McGill JB, Al-Aly Z

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Exenatide exerts a PKA-dependent positive inotropic effect in human atrial myocardium: GLP-1R mediated effects in human myocardium

In essence, GLP-1 appears to modulate the DMN, pushing it in the direction of balance

Efficacy of Ertugliflozin on Heart Failure-Related Events in Patients with Type 2 Diabetes Mellitus and Established Atherosclerotic Cardiovascular Disease: Results of the VERTIS CV Trial