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Cardiovascular Evidence# LEADER Trial (Liraglutide)# The LEADER trial (Marso et al., NEJM 2016) enrolled 9,340 patients with T2D and high CV risk, followed for median 3.8 years: 3-point MACE: HR 0.87 (95% CI 0.78-0.97, p=0.01) -- 13% reduction Cardiovascular death: HR 0.78 (22% reduction) All-cause mortality: HR 0.85 (15% reduction) Liraglutide was the first GLP-1 agonist to demonstrate cardiovascular benefit, and LEADER remains a landmark trial in the class

Craciun CI, Neag MA, Catinean A et al (2022) The relationships between Gut Microbiota and Diabetes Mellitus, and treatments for diabetes Mellitus

defines the first week of taking Mounjaro as hell, as there was much nausea and vomiting

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Ambos tratamientos actan reduciendo el hambre y el apetito mediante seales enviadas al cerebro que indican sensacin de saciedad

The appropriate amount depends on your individual calorie targets and overall dietary plan, which should be discussed with your prescribing clinician or registered dietitian