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While these werent direct head-to-head trials (different studies, different populations), the magnitude of difference is striking

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(2R)-4-oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

But it is a serious reframe, made by serious people in serious journals, and it changes who the matching problem is for
doi: 10.1080/00207454.2018.1526795 [DOI] [PubMed] [Google Scholar] 85.Jing GC, Zhang MR, Ji C, Zuo PP, Liu YQ, Gu B

The Cleveland Clinic analysis found that many patients who stopped GLP-1 therapy later restarted, sometimes with the same medication, sometimes switching to an alternative