![glp-1 anxiety depression Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] Depression: Oranges, exercise, and GLP-1](https://www.preprints.org/frontend/picture/ms_xml/manuscript/c9c3cd16d3db64faa79714c50b5bb790/preprints-181961-g001.png)
glp-1 anxiety depression Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] Depression: Oranges, exercise, and GLP-1
Description
Wegovy (semaglutide) acts on the GLP-1 pathway only, and is also FDA-approved specifically for chronic weight management
![glp-1 anxiety depression Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] Depression: Oranges, exercise, and GLP-1](https://media.post.rvohealth.io/wp-content/uploads/sites/3/2025/03/news-roundup-20240313-1296x728-header-1024x575.jpg)
I also checked Sprouts terms and conditions page and found a statement saying their services are available in all 50 states
Microglial GLP-1R activation in the TNC may suppress the central sensitization of CM by regulating TNC microglial activation via the PI3K/Akt pathway
![glp-1 anxiety depression Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] Depression: Oranges, exercise, and GLP-1](https://lookaside.instagram.com/seo/google_widget/crawler/?media_id=3931922166656164606)
and Aroda et al
![glp-1 anxiety depression Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] Depression: Oranges, exercise, and GLP-1](https://lookaside.fbsbx.com/lookaside/crawler/media/?media_id=1050290233751571)
Reputational risks : Adverse outcomes from compounded medications could lead to negative media coverage, damaging the employers reputation
![glp-1 anxiety depression Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] Depression: Oranges, exercise, and GLP-1](https://preview.redd.it/glp1-causing-depression-v0-mzk83npevm7e1.jpeg?auto=webp&s=d118c8c31222ed1c9fd6d25a10d2da4903424a0f)
Of those, 4 RCTs [1, 2, 4] as SURMONT-OSA Trial by Malhotra et al
![glp-1 anxiety depression Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] Depression: Oranges, exercise, and GLP-1](https://www.healio.com/~/media/slack-news/fm_im/misc/infographics/2026/03_march/pc0326taylor_graphic_01_web.jpg)
