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Description

Targeted GLP-1 companion supplementation, guided by laboratory values and clinical context, may help support nutritional adequacy during GLP-1 therapy

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GLP-1 secretion by proteins/amino acids Protein and amino acid stimulation of GLP-1 secretion has been demonstrated in murine primary colonic L-cell cultures [260,302], in GLUTag cells [256,259], in human NCI-H716 cells [251,303] and in the isolated perfused rat ileum or colon [250,304] as well as in vivo in mice [305], rats [256,306], and humans [307,308]

Using propensity matching, the researchers compared 2,894 patients taking a GLP-1 receptor agonist at baseline with 2,894 patients not taking one at baseline