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Previous work in humans and rodents has demonstrated widespread transcriptomic changes early after RYGB during active weight loss and during subsequent weight-stable periods 25 , which could explain changes in the metabolic phenotype of the liver

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Most likely, the mechanism involves stress from rapid weight loss and reduced calorie intake, leading to telogen effluvium

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Despite its impressive clinical trial results, retatrutide is being investigated for its long-term efficacy and safety