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Personalized treatment plans are available starting at $149 CAD/month, making effective, affordable GLP-1s accessible to Canadians for whom cost has long been a barrier to treatment

A study led by Professor Rong Xu at Case Western Reserve School of Medicine found that adults with type 2 diabetes taking semaglutide had a notably lower incidence of dementia compared to those on other antidiabetic medications, particularly among women and older adults

In vitro signaling studies demonstrated that tirzepatide was able to activate the GIP receptor with comparable potency to native GIP (57)

Unveiling Tirzepatides therapeutic spectrum: a dual GIP/GLP-1 agonist targeting metabolic, neurological, and cardiovascular health

GLP1: the early steps of a success story

The first identified incretin was a gastric inhibitory peptide (GIP) with the activity of inhibiting the secretion of gastric acid, which was isolated from porcine small intestines ( + channel and depolarize the cell membrane, while also activate the voltage-dependent Ca 2+ channel, causing a Ca 2+ inflow and the generation of action potentials ( 2+ release by activating inositol triphosphate (IP3)