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Ethical Principles for Medical Research Involving Human Subjects

Patients were also excluded if they met the ASA physical status classification of ASA 4 (patients with severe systemic disease threatening life) or ASA 5 (patients who were not expected to survive without surgery) (11)

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Effectiveness of medications used to attenuate antipsychotic-related weight gain and metabolic abnormalities: a systematic review and meta-analysis
These medicines improve health through reduction of blood glucose and body weight, by attenuation of inflammation and via direct activation of receptors in target tissues