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Tirzepatide for reduction of morbidity and mortality in adults with obesity: rationale and design of the SURMOUNT MMO trial

Weight reduction: Clinical trials report substantial bodyweight loss (up to ~11 kg more than GLP1 RA comparators over 26 weeks at higher doses) [3] [4]

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Clinical efficacy studies of various unimolecular dual and triple agonists targeting the GLP- 1 receptor, GIP receptor, and glucagon receptor have shown promising results when used alone or in conjunction with approved hypoglycemic medications