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Description
Two studies on DDI between GLP1RAs and COCs enrolled post-menopausal women [17, 18] and three studies enrolled pre-menopausal women [14, 15, 21]
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Secreted GLP-1 then impedes gastrointestinal motility at the level of myenteric neurons by inhibiting downstream signaling of nitric oxide and cyclic adenosine monophosphate (cAMP) dependent pathways that inhibit vagal activity [10]
37 They found that only [Aib 8 ]- and [Gly 8 ]-GLP-1(736)-NH 2 exhibited comparable receptor binding to GLP-1 (IC 50 of 0.45 and 2.8 nM, respectively, compared to 0.78 nM of GLP-1)
4.2 Limitations This meta-analysis has several limitations
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