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VX-765 is currently undergoing clinical investigation in epilepsy (clinical trial identifier: NCT01048255) and psoriasis (clinical trial identifier: NCT00205465) without any reports of toxicity yet

If proven true, this would add to our knowledge about the gut-brain connection [19]

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With continuous therapy, your appetite hormones stabilize at their treated state, your brain adapts to sustained satiety signals, and your weight plateaus rather than rebounds

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In summary, GIP effects on the CV system are conflicting, with amplification and inhibition of GIPR signaling both having beneficial and detrimental CV effects, depending on the species and the genetic and/or experimental model