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A administrao de exendina-4 em modelos animais resultou na reduo da dor, inibio de fatores inflamatrios como IL-1 e TNF-, alm de atenuar a ativao da microglia um processo fundamental na proteo neuronal

5 At one time, it was theorized that there was a single hormone responsible for this activity, but it was discovered that two hormones secreted from the intestines are primarily responsible for the incretin effect, GLP-1 and glucose-dependent insulinotropic polypeptide (GIP)

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By enhancing insulin sensitivity, these medications may help reduce such discomfort