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During insulin resistance (IR), glucose metabolism converges in mitochondria via insulin signalling causing diabetes progression [57]

These metabolic improvements not only support effective weight loss but also reduce long-term risks associated with diabetes, heart disease, and obesity-related complications

muciniphila and the symbiotic microbiota Given the inherent limitations of single-strain probioticssuch as their ecological niche specificity, limited functional diversity, and the complex dynamics of the gut ecosystemresearchers have increasingly turned to the development of multi-strain consortia with complementary functionalities, which offer a more effective strategy for regulating the intestinal microecology [113, 114]

2023, doi: 10.1001/jama.2023.12055

Differences between groups were compared via two-tailed unpaired t tests for two groups, one-way analysis of variance (ANOVA) followed by Dunnetts multiple comparison test for multiple groups, or two-way repeated-measures ANOVA followed by the Bonferroni multiple comparison test for multiple groups and time courses

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