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Sensitivity analysis was not performed in some outcomes because of the small number of studies remaining (NAS), and there were no studies with a high risk of bias (NASH resolution, liver fat contents by CAP)

Obesity alone increases the risk of headache and migraine by 27%, suggesting that weight loss itself is an important goal in the symptomatic treatment of IIH (20)

J Clin Med Res

Analysis of subgroup of patients with HF in the EXSCEL trial revelaed that use of once-weekly exenatide reduced the risk of all-cause mortality in patient without HF (HR 0.79 [95% CI, 0.680.92]), while in patients with baseline HF no effect was observed (HR, 1.05 [95% CI, 0.851.29) (67)

Semaglutide is the active ingredient found in widely used medication prescribed for type 2 diabetes (Ozempic) and obesity (Wegovy)

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