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Notably, the Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trial, the first dedicated kidney outcome trial evaluating canagliflozin in people with type 2 diabetes mellitus and CKD, demonstrated a substantial reduction in the risk of kidney events [46]

In: Talley NJ, GR Locke, Saito YA, editors

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In a 24-week study, patients were randomized to receive either glimepiride alone or in combination with metformin, or glimepiride and sitagliptin or both agents also in combination with metformin