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This complication occurred despite the absence of other medications known to impair gastrointestinal motility, strengthening the temporal association with semaglutide [14]

A 2022 systematic review and meta-analysis published in JAMA Internal Medicine found that GLP-1 receptor agonists were associated with increased risks of biliary disease compared to other diabetes medications, with higher risk observed at weight-loss doses and with longer duration of treatment

Fatigue: Some people report feeling tired during the first few days after increasing their dose

Diarrhea frequently arises during dose escalation, with the increased risk associated with higher doses

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