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This makes it one of the most powerful tools we have right now for people with TRD

However, maintaining adequate protein intake and participating in regular resistance training can significantly reduce muscle loss

Beyond lowering blood sugar, metformin may also: Cause weight loss Help manage polycystic ovarian syndrome (PCOS) symptoms Improve insulin sensitivity Manage gestational diabetes Manage prediabetes So, while berberine may be an option for someone who prefers not to take prescription medication or cannot tolerate them, metformin remains the more effective, safe and proven choice

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p = 0.0003) in 3533 patients with type 2 diabetes and chronic kidney disease, over a median follow-up of 3.4 years [96,97]

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