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Description

Activating GLP-1R inhibited TGF-1 + IL-1-induced fibroblast activation by disrupting the interaction between the NLRP3 inflammasome and PFKFB3-driven glycolysis and subsequently prevented lactate-mediated histone lactylation to reduce pro-fibrotic gene expression

This creates a beneficial cycle: lifestyle changes that promote GLP-1 release support weight management, which in turn may enhance GLP-1 function

But neither strategy is foolproof

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