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Most patients notice reduced appetite and early weight loss within 714 days of beginning semaglutide or tirzepatide

Data availability Source data are provided with this paper

The gold standard for oral weight loss was Phentirmin , the patients must not have previous cardiac concerns before starting this medication due to it's potency

The magnitude varies significantly between individuals: STEP 4 Trial : Participants who stopped semaglutide after 20 weeks regained approximately 7% body weight over next 48 weeks (compared to losing an additional 8% who continued medication) Real-World Studies : Variable outcomes

These changes are temporary and typically resolve within 2-3 months of weight stabilization

In the UK, access is governed by NICE guidance, with specific criteria for diabetes management and weight loss indications