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I'm answering all of these as always with evidence

doi:10.3945/ajcn.114.084038

These changes can dysregulate hunger and satiety signals, making appetite control difficult even after adopting a strict gluten-free diet

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Gastroenterology 1985

4 Discussion The improvement of semaglutide on obese individuals is significant, and the main mechanism of this type of GLP-1RA is to stimulate GLP-1R, triggering activation of several metabolic pathways involved in insulin secretion, lipid metabolism, energy expenditure, cell survival, anti-apoptotic signaling, and oxidative stress prevention in tissues such as the pancreas, central nervous system, heart, muscles, kidneys, and intestines (Rowlands et al., 2018)