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Together, these findings highlight the potential importance of disease context in modulating GLP1R expression and responsiveness

However, the GI side effects (particularly vomiting and diarrhea) can cause dehydration, which hits people with existing kidney disease much harder

Others experience fatigue, especially early in treatment when their caloric intake drops significantly

If caused by food (e.g., licorice, iron supplements) or medications (e.g., bismuth-based drugs), its usually harmless

If youre unsure, check the patient leaflet or ask your healthcare provider

A one-size-fits-all approach to weight loss rarely yields sustainable results