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doi: 10.1016/j.cmet.2008.12.004

Compared with placebo, empagliflozin significantly reduced the composite endpoint risk of cardiovascular death or HF hospitalization

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This risk was more pronounced in weight-loss scenarios, where higher doses of GLP-1RAs, such as those used with liraglutide and semaglutide, resulted in more significant weight reduction and a correspondingly higher incidence of gallstone-related complications

His interest in this area had in part been inspired by his time as both an undergraduate and then a doctoral student at the University of Edinburgh with Sharpey-Schafer

Caffeine and alcohol: Both can act as stimulants or irritants to the digestive tract