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GLP-1RAs provide cardioprotective benefits through glycaemic and non-glycaemic effects, including improved insulin secretion and action, body-weight loss, blood-pressure lowering and improved lipid profile, as well as via direct effects on the heart and vasculature

-1 Incretins have an important role in glucose homeostasis, regulation of appetite, energy expenditure and immunity

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A mitochondrial switch ("SLC25A45") controls whether mitochondria burn fat or carbohydrate, and removing it (in mice) makes GLP-1 drugs stop working for fat loss entirely

There is still a lot we dont know about the potential side effects of drugs used for weight loss.