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Have a history of pancreatitis as there is a slight increased risk of developing pancreatitis on this medication Have gastroparesis due to it slowing down gastric emptying which can worsen gastroparesis Have hypertriglyceridemia, or extremely high triglyceride levels As with other agents in this class, tirzepatide has a boxed warning regarding rodent thyroid C-cell tumor findings and the uncertain relevance to humans

Keep electrolytes balanced: Tirzepatide-related GI symptoms can affect mineral absorption

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If symptoms last more than a couple of days or keep returning, track meals, hydration, and timing, then check in with your clinician to tailor your plan

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If a Clinical Difference Statement is not provided, the prescription will be cancelled and the patient will be referred to the commercially available product, if available