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Intolerable side effects Persistent nausea, vomiting, severe GI symptoms, or other side effects that do not resolve with dose adjustment are legitimate clinical reasons to stop

GLP-1 injectable technology offers less painful, finer needles and more dosing options than once-daily oral treatment

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Third, these new results show convincingly that major adverse CV events benefits are independent of the structural basis of the GLP-1 receptor analogue, assuaging concerns that exendin-4-based agonists are less effective than human GLP-1-based molecules.

A promising explanation could be represented by the complex interplay between inflammation and metabolism, which is still largely unknown in the field of IBD management

However, this does not definitively exclude the possibility that some patients may experience back pain during therapy