tirzepatide lindale Compounded for Weight Management Personalized Tirzepatide Treatment

Train Keeps A-Rollin The Santa Train enters its 78th run Thanksgiving weekend when CSX Railway hosts its annual 110-mile holiday excursion run between downtown Kingsport and Shelby, KY

Mechanism of Action Selective 1 blockade mainly affects heart and kidneys heart rate (negative chronotropy) myocardial contractility (negative inotropy) renin release from the kidneys angiotensin II BP Minimal effect on 2 receptors (lungs, vasculature) safer in mild asthma than non-selective beta-blockers Pharmacokinetics Absorption: Oral, 4050% bioavailability Distribution: Limited CNS penetration (less sedation) Metabolism: Minimal (mostly excreted unchanged by kidneys) Half-life: ~67 hours Excretion: Renal Clinical Uses Hypertension: Alone or in combination Angina pectoris: myocardial oxygen demand Acute myocardial infarction: Secondary prevention Arrhythmias: Atrial fibrillation, supraventricular tachycardia Migraine prophylaxis: Off-label use Hyperthyroidism / thyrotoxicosis: Controls tachycardia Adverse Effects Cardiovascular: Bradycardia, hypotension, heart block, worsening heart failure CNS: Fatigue, dizziness Metabolic: Mild triglycerides, HDL

doi: 10.1111/bph.15508 69

[1] [3] Whilst these mechanisms contribute to improved glycaemic control and weight reduction, they also account for one of the most commonly reported adverse effects: nausea

3.) Kouranos V, Sharma R

Maintaining muscle mass is essential for metabolic health and physical function, especially in older persons