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2015Lixisenatide in patients with type 2 diabetes and acute coronary syndrome

This outcome is thought to be an effect of all medications that increase GLP-1, because of both an increase in SDF-1-alpha and capillary density due to increased hypoxia-inducible factor 1-alpha and vascular endothelial growth factor

doi: 10.1038/s41366-018-0303-y 135 HajnalAKovacsPAhmedTMeirellesKLynchCJCooneyRN

This may have set the scene for an adaptive conflict where on one side selection would favour tolerance to a spike in GLP-1 in blood as a result of envenomation and on the other increased potency as a venom component

The relationship between GLP-1 receptor agonists and generalized skin sensitivity remains unclear, as there is no official established link between these medications and widespread sensitive skin as a direct pharmacological effect