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Less common but important GLP-1 agonist side effects include increased heart rate in some patients, potential increased risk of gallbladder disease with rapid weight loss, and theoretical concerns about pancreatitis and thyroid C-cell tumors (though these risks remain controversial and may not be clinically significant)

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Meta-regression analyses were conducted with STATA statistical software package, version 18.1 (Stata Corp, College Station, TX, USA)

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The best time of day to take tirzepatide for weight loss is not specified by FDA guidelines, as clinical evidence shows the medication works effectively regardless of when you inject it