semaglutide dosage vs tirzepatide dosage TrimRX Mounjaro vs. Ozempic: Effectiveness, Side

N Engl J Med 270:431 32.1 Frates MC, Benson CB, Doubilet PM, Kunreuther E, Contreras M, Cibas ES, Orcutt J, Moore FD Jr, Larsen PR, Marqusee E, Alexander EK

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Upon liver injury, hepatic stellate cells (HSCs), the major players in liver fibrosis, are activated and transdifferentiated into myofibroblast-like cells

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Beyond weight outcomes, the Phase 2 obesity trial also reported improvements in several cardiometabolic markers, including: Reductions in waist circumference Improvements in fasting glucose and insulin sensitivity Favourable changes in blood pressure and lipid profiles Phase 3 trials understood to form part of the TRIUMPH programme are now underway, evaluating retatrutide in broader populations including people with type 2 diabetes and cardiovascular disease