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The higher the dose of Zepbound, the more weight a person is likely to lose, according to clinical trial data

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Originally developed for type 2 diabetes, clinicians quickly recognized their powerful impact on weight loss

Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic -cells in mouse models of -cell regeneration

2025;39(2):e153e154

Furthermore, GLP-1 has the ability to decrease gastric acid secretion and postprandial gastric emptying, limit gastric and duodenal peristalsis through vagus nerve inhibition, and raise pylorus pressure, all of which contribute to a decrease in appetite, weight loss, and the so-called "ileal braking" effect [121]