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K.OnderK.Schuller-GoetzburgP.PlakysG.et al (2020)

Weight loss still depends on consistent habits and medical follow-up

Data from a study with high-fat diet mice has also linked the learning and memory restorative benefits of metformin in the diet (250 mg/kg/day) to the microbiota with positive data from a fecal transplantation protocol [(118): Table 2 ]

Set realistic, specific goals for weight and habits

Case reports indicate that metreleptin can markedly improve hepatic steatosis and ALT levels in pediatric patients with congenital leptin deficiency and can be considered in the rare clinical scenario of pediatric obesity and hepatic steatosis due to leptin deficiency [167,168]

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