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Introduction While the gut hormones secretin and gastrin were discovered almost two decades earlier ( Although insulin therapy is often indicated in poorly controlled Type 2 diabetes mellitus (T2DM), this condition is more often managed with diet plus an array of medications that augment remaining endogenous insulin production and function

Common side effects include nausea, diarrhea and constipation
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It increases fatty acid oxidation, enhances glucose uptake, and promotes mitochondrial biogenesis

However, in rats, GLP-1 elevation of BP is preserved upon pretreatment with reserpine, propanolol or phentolamine, thus indicating that the hypertensive effect of GLP-1 does not exclusively depend on catecholamine signaling [634]
