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Please contact us regarding any questions you might have regarding potential semaglutide claims.

Consider adjusting your dose: Most GI side effects happen during dose increases, and some people feel better when they stay at a lower dose for longer

Things that are not captured in trial averages Your personal tolerance for each medication's side effect profile How your existing medications interact with each option Your insurance coverage and out-of-pocket cost for each medication Whether you have other health conditions that make one option more appropriate than another Whether you prefer or need a daily vs weekly injection routine for practical reasons None of these medications are a standalone solution

Make sure you coordinate with them, says Gorrepati

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A 2025 meta-analysis in JAMA Psychiatry found no increase in depression or suicidality with GLP-1 medications versus placeboin fact, some trials showed slightly lower depressive symptoms in the GLP-1 groups