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When this milieu is perturbed, brain hyperglycemia, brain glucotoxicity, and brain insulin resistance can ensue and interfere with insulin signaling, a key pathway to cognitive function and neuronal integrity

Oral semaglutide (Rybelsus, Wegovy pill) can cost $0 to $1,400+ per month depending on drug, insurance, & other factors

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The wild card-to-uncertainty about GLP-1 meds growth will be reimbursement: spending will continue to accelerate with upside if more widely reimbursed, IQVIA projects

Results Compared with D&E, semaglutide 2.4 mg in combination with D&E generated an additional 0.1049 QALYs and a 2685 increase in costs over 40 years, resulting in an incremental cost-effectiveness ratio of 25,589/QALY