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Of note, even before the introduction of the newer classes of medications, multifactorial, target-driven therapies addressing glycaemic, blood pressure and lipid control that incorporated reninangiotensin system blockade, the use of statins and attention to lifestyle factors significantly reduced the progression to end-stage kidney disease by about 50% in people with type 2 diabetes, hypertension and microalbuminuria

The DPP-4 cleavage at postproline peptide bonds inactivates peptides and/or generates new bioactive peptides, thereby regulating diverse biological processes

Week-by-week weight loss should still be relatively minor, and you may not see any physical changes just yet, but dont be disheartened

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Common UK examples include semaglutide (Ozempic, Wegovy, Rybelsus), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)