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Depressed patients are often characterized by elevated blood cortisol levels and changes in the circadian secretion of this hormone, an increased number of corticotropin-releasing hormone (CRH)-expressing neurons in the hypothalamic paraventricular nucleus (PVN), as well as an impairment in a negative feedback mechanism, which can be measured in the dexamethasone suppression test [70, 71]

Who May Be a Candidate for GLP-1 Weight-Loss Injections

Association of Glucagon-Like Peptide-1 Receptor Agonist Use With Risk of Gallbladder and Biliary Diseases: A Systematic Review and Meta-analysis of Randomized Clinical Trials JAMA Internal Medicine 2022 JAMA 2 U.S

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This helps explain why payer coverage restrictions for GLP-1s used for obesity continue to be a hurdle for patients who seek access

Before starting any GLP-1 medication, patients should undergo thorough medical evaluations to ensure these drugs are appropriate for their health conditions