nejm tirzepatide SURMOUNT-1 (NEJM 2022) tested — a dual GIP/GLP-1 receptor agonist — in 2,539 adults with obesity and achieved up to 20.9% mean weight loss at the highest dose. 57% of participants 🔴Tirzepatide as Compared with Semaglutide

The NHS recommends drinking 6-8 glasses of fluid daily, though patients with heart failure, kidney disease or other conditions requiring fluid restriction should follow their clinician's specific advice

On September 16, 2025 , the FDA issued warning letters to more than 50 compounding pharmacies and telehealth companies , including Hims & Hers , for selling unapproved GLP-1s and making misleading claims

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Cagrilintide is an amylin analog it works through a completely different receptor system than GLP-1

In studies with rats, Mounjaro's active ingredient, tirzepatide, caused an increase in thyroid C-cell tumors