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Studies have indicated that SMAD3, SMAD4, and SMAD5 have close relationships with apoptosis of granulosa cells, the main mechanism underlying follicular atresia (279, 280)

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234,235 Glucagon is a hormone secreted by pancreatic -cells that stimulates the liver to release glucose

[1] This dual effect helps improve glycemic control without causing significant hypoglycemia in most patients, though the risk increases when combined with insulin or sulfonylureas