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PMID 30780817

Corresponding EHR data for UKBB participants were sourced from the UK Biobank Resource, which operates under the auspices of the UK Biobank Steering Committee and has received ethical approval from the North West Multi-centre Research Ethics Committee

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Consistency matters more than precision Weight loss on tirzepatide is driven by sustained caloric deficit, which is driven by consistent appetite suppression, which is driven by steady drug levels

If patients receive GLP1 medications outside their primary health system (for example, from telehealth) or change providers during the treatment, the EHR data collected in our study may not capture the full course of treatment, and this may explain our observation of generally shorter treatment durations, and hence less weight loss, recorded in EHRs

Without a plan, this rebound can increase the risk of gestational diabetes later in pregnancy