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The escalation protocol allows the body to adapt gradually to increasing medication levels

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GLP-1 therapy requires monitoring for respiratory effects, nutritional adequacy, and medication interactions

In the SURPASS clinical trial program, gastrointestinal adverse events were generally mild to moderate in severity and tended to decrease over time as patients developed tolerance to the medication

This is lower than the 1-1.9% reduction achieved with semaglutide but still offers a noticeable improvement in glycemic control for people with type 2 diabetes

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