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Receptor desensitization and tachyphylaxis When receptors are exposed to an agonist continuously, they can become less responsive over time

First, manufacturing environment

The pattern is clear: higher doses produce greater effects, though with diminishing returns at the top end

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Instead, doses increase gradually over a minimum of 20 weeks to reach the maximum, and this escalation period explains why results are modest early on

GLP-1 receptor agonists carry a theoretical risk of thyroid C-cell effects, and lupus patients have higher rates of thyroid autoimmunity