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Heart failure therapy by GLP-1RAs Although a meta-analysis of large-scale clinical trials suggested that GLP-1RAs reduce heart failure hospitalizations (HHF) by approximately 10% in patients with diabetes at high cardiovascular risk [22, 23], the treatment effects on the risk of HHF in individual trials other than AMPLITUDE-O were not significant (Tables 1, 2)

It has been reported that airway inflammation serves a significant role in COPD, although the precise role remains unclear (5)

b Overweight, body mass index (BMI) of 27 kg/m 2 or greater

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