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Protocol: Track all food intake for 7 consecutive days

This conversation should cover: The medical necessity of both treatments The expected duration of prednisolone therapy (short-term versus long-term) Individual risk factors, particularly regarding diabetes or prediabetes Realistic expectations about weight loss outcomes whilst on corticosteroids Monitoring requirements for blood glucose and other metabolic parameters The decision to use both medications should be individualised , weighing the clinical benefits of each treatment against potential complications

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If there is uncertainty about whether the medication remained within safe temperature limits during shipping, patients should contact their pharmacy before using the medication

Welcome back to our new eight-part series that I am calling On My Heart and Mind

The observation that a high dose of peripherally administered semaglutide and strong chemogenetic activation of PPGs suppress intake in an additive manner (Brierley et al., 2021) argues against highly convergent signalling mediating hypophagia in this context