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This delayed emptying helps you eat less because you feel fuller for longer, which is one of the main ways GLP-1s support weight loss

Semaglutide suppresses appetite significantly, and this suppression can begin within days of the first dose

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Several plausible mechanisms may hypothetically explain why patients on GLP-1 therapy experience muscle cramps, even in the absence of a direct pharmacologic effect

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This effect requires GLP-1R expression in brain neurons, as shown in mice lacking GLP-1R in neuron-targeting Wnt1- or nestin-expressing domains ( Glp1r Wnt1/ and Glp1r Nes/ ), and by intracerebroventricular injection of exendin-9-39, a GLP-1R antagonist that suppresses activation of brain GLP-1R signaling