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Conclusion This study does not declare explicit risks, still findings highlight 14 new signals warranting further investigation, including postmenopausal haemorrhage, menstrual disorder, skin sensitization, sleep disorder, Wernickes encephalopathy, muscle atrophy, neck mass and lymph node pain

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Naltrexone blocks the brains reward system, reducing the pleasure response to food and helping control compulsive eating behaviors

The gutgenital tract microbiota interface and immune crosstalk is a recognised concept in womens health, and diabetes is associated with alterations in vaginal microbiota ecology, particularly around menopause transitions