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At 3 months, patients achieved an average weight loss of 5.9%, and at 6 months, the weight loss increased to 10.9%

307 The JAK/STAT3 signaling pathway, one of the most important modes of STAT signaling, regulates cell function through cytokine-receptor interactions, activation of the JAK protein kinase, and phosphorylation of the STAT protein

In addition, GLP-1/glucagon and GLP-1/GIP dual receptor agonists and GLP-1/GIP/glucagon triple receptor agonists have shown the potential to reduce blood glucose levels and body weight through their effects on islets and peripheral tissues, improving beta cell function and stimulating energy expenditure

While GLP-1RAs were initially developed for glycemic control in T2DM, accumulating evidence supports their utility in managing obesity independent of diabetes

Sergey Terushkin, MD, FACS is a fellowship-trained bariatric surgeon with experience in bariatric surgery, obesity medicine, medical weight loss, and long-term weight management

This could include notes from previous doctors, records of participation in weight management programs, or even diaries you kept