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IRS, insulin receptor substrates

Cyanocobalamin: Converted in vivo to the active coenzyme forms methylcobalamin and adenosylcobalamin

Initially approved for type 2 diabetes, they are now also FDA-approved for weight management, cardiovascular risk reduction, obstructive sleep apnea, and metabolic-associated liver disease (steatohepatitis)

In addition to their known effect on insulin response, GLP-1RAs are hypothesized to reduce proinflammatory cytokine signaling and alter surfactant production potentially improving both airway resistance and lung compliance (Kanwar et al

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