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In addition, insulin has multiple other roles observed in tissue studies and animal models of AD, including effects on synaptic plasticity, dendritic spine formation, transmitter turnover, proteostasis including clearance of A and tau, vascular function, lipid metabolism, and inflammation [96]

Additional considerations include genital mycotic infections (yeast infections), which occur more frequently with SGLT2 inhibitors due to elevated urine glucose, and acute kidney injury in rare cases if dehydration becomes severe

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