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Although past meta-analyses reported substantial reductions in MACE with DPP-4 inhibitors [23], their conclusions were based on studies with small sample sizes and limited numbers of cardiovascular events, which have not been confirmed by the four CVOTs specifically designed to assess the CV safety of DPP-4 inhibitors
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Dapagliflozin currently has the lowest eGFR cut off for the indication of CKD at above 25 mL/min/1.73 m 2
